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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Kinesin-BRD 9876
BRD 9876

Chemical Structure : BRD 9876

CAS No.: 32703-82-5

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BRD 9876 (BRD9876)

货号: PC-62341Not For Human Use, Lab Use Only.

BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM).
BRD 9876 enhances Eg5-mediated microtubule stabilization.

物理化学性质&存储条件

分子量 234.302
分子式 C16H14N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-tert-Butyl-2,3-naphthalenedicarbonitrile

参考文献

1. Chen GY, et al. ACS Chem Biol. 2017 Apr 21;12(4):1038-1046.

2. Chattopadhyay S, et al. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00030-3.

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