BRD 8899 | STK33 inhibitor | Probechem Biochemicals

Chemical Structure : BRD8899

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BRD8899 (BRD-8899, BRD 8899)

货号: PC-62028Not For Human Use, Lab Use Only.

BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).

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生物&药学活性

BRD8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).
BRD8899 exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%.
BRD8899 shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells.

物理化学性质&存储条件

分子量	362.45
分子式	C17H22N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(((2S,4R)-4-(4-Methylisoquinoline-5-sulfonamido)pyrrolidin-2-yl)methyl)acetamide

参考文献

1. Luo T, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5.

BRD8899 (BRD-8899, BRD 8899)

生物&药学活性

物理化学性质&存储条件

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BRD8899 (BRD-8899, BRD 8899)

生物&药学活性

物理化学性质&存储条件

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