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首页-小分子抑制剂&激动剂-Others-Other Targets-BRD8518
BRD8518

Chemical Structure : BRD8518

CAS No.: 1565828-01-4

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BRD8518 (BRD 8518)

货号: PC-38411Not For Human Use, Lab Use Only.

BRD8518 is a specific small molecule TRIB1 inducer, modulates expression of the key genes involved in VLDL production and in LDL clearance in HepG2 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BRD8518 is a specific small molecule TRIB1 inducer, modulates expression of the key genes involved in VLDL production and in LDL clearance in HepG2 cells.
    BRD8518 activity is MEK1/2 dependent and the treatment of HepG2 cells with BRD8518 stimulates ERK1/2 phosphorylation.

    物理化学性质&存储条件

    分子量 607.630
    分子式 C33H32F3N3O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

    参考文献

    1. Nagiec MM, et al. Medchemcomm. 2018 Sep 14;9(11):1831-1842.

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