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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-BRD7389
BRD7389

Chemical Structure : BRD7389

CAS No.: 376382-11-5

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BRD7389 (BRD-7389, BRD 7389)

货号: PC-62045Not For Human Use, Lab Use Only.

BRD7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively.

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50 mg ￥880 In stock
100 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively.
BRD7389 inhibits not only RSK enzymes, but also members of several other kinase families.
BRD7389 causes alpha-cells to adopt several morphological and gene expression features of a beta-cell state.
BRD7389 also blockes carbachol-stimulated cell proliferation in SNU-407 cells.

物理化学性质&存储条件

分子量 366.4
分子式 C24H18N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

参考文献

1. Fomina-Yadlin D, et al. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104.

2. Bain J, et al. Biochem J. 2007 Dec 15; 408(3):297-315.

3. Park YS, et al. Mol Cell Biochem. 2012 Nov;370(1-2):191-8.

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