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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-HMG-CoA Reductase (HMGCR)-BRD7116
BRD7116

Chemical Structure : BRD7116

CAS No.: 329059-55-4

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BRD7116 (BRD-7116)

货号: PC-45539Not For Human Use, Lab Use Only.

BRD7116 selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase (HMGCR).

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD7116 selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase (HMGCR).
BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture.
BRD7116 shows limited activity against normal HSPCs and AML cell lines (>10 uM).

物理化学性质&存储条件

分子量 496.6614
分子式 C28H36N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 48 mg/mL
Chemical Name/SMILES

Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)

参考文献

1. Hartwell KA, et al. Nat Chem Biol. 2013 Dec;9(12):840-8.

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