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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-BRD6989
BRD6989

Chemical Structure : BRD6989

CAS No.: 642008-81-9

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BRD6989 (BRD-6989, BRD 6989)

货号: PC-60893Not For Human Use, Lab Use Only.

BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex.
BRD6989 displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).
BRD6989 inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs, selectively upregulates IL-10 with EC50 of 1 uM.

物理化学性质&存储条件

分子量 264.332
分子式 C16H16N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

参考文献

1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.

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