BRD6851 |CAS:1396152-06-9 Probechem Biochemicals

Chemical Structure : BRD6851

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BRD6851 (BRD 6851)

货号: PC-62181Not For Human Use, Lab Use Only.

BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist.

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生物&药学活性

BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist; an allosteric inhibitor of SAG but a competitive inhibitor of purmorphamine-induced Gli1 expression.

物理化学性质&存储条件

分子量	489.393
分子式	C25H26Cl2N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorobenzyl)-2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetamide

参考文献

1. Dockendorff C, et al. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813.

BRD6851 (BRD 6851)

生物&药学活性

物理化学性质&存储条件

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BRD6851 (BRD 6851)

生物&药学活性

物理化学性质&存储条件

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