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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BRD5529
BRD5529

Chemical Structure : BRD5529

CAS No.: 1358488-78-4

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BRD5529 (BRD-5529;BRD 5529)

货号: PC-63321Not For Human Use, Lab Use Only.

BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM.

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10 mg ￥1480 In stock
25 mg ￥2480 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM.
BRD5529 directly and selectively bind CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways.
BRD5529 selectively inhibits Dectin-1- mediated CARD9 activation, while leaving LPS-activated signaling intact.

物理化学性质&存储条件

分子量 465.554
分子式 C25H31N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4'-carbamoyl-[1,4'-bipiperidin]-1'-yl)-5-(4-methylbenzamido)nicotinic acid

参考文献

1. Leshchiner ES, et al. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397.

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