BRD4 degrader ZZ1

Chemical Structure : BRD4 degrader ZZ1

加入收藏

货号: PC-26562Not For Human Use, Lab Use Only.

BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1.
ZZ1 binds the ligand-binding pocket in YPEL5 that corresponds to CRBN CTD.
ZZ1 is a metabolically activated prodrug of a charged MGD.

物理化学性质&存储条件

分子量	658.16
分子式	C30H29ClFN5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (S)-2-(4-(4-(3-chloro-4-(fluorosulfonyl)benzamido)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

参考文献

1. Zhuang Z, et al. Nat Chem Biol. 2026 Apr 6. doi: 10.1038/s41589-026-02182-5.