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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-BRD4592
BRD4592

Chemical Structure : BRD4592

CAS No.: 2109805-80-1

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BRD4592 (BRD-4592)

货号: PC-70214Not For Human Use, Lab Use Only.

BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.
    BRD4592 is highly effective in vivo.

    物理化学性质&存储条件

    分子量 282.318
    分子式 C17H15FN2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,3S,4R)-3-(2'-fluoro-[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile

    参考文献

    1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96.

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