BRD3731 | GSK3β inhibitor | Probechem Biochemicals

Chemical Structure : BRD3731

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BRD3731 (BRD-3731, BRD 3731)

货号: PC-63312Not For Human Use, Lab Use Only.

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).

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生物&药学活性

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
BRD3731 displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM.
BRD3731 induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.

物理化学性质&存储条件

分子量	377.532
分子式	C24H31N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4,7,7-trimethyl-3-neopentyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one

参考文献

1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.

BRD3731 (BRD-3731, BRD 3731)

生物&药学活性

物理化学性质&存储条件

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BRD3731 (BRD-3731, BRD 3731)

生物&药学活性

物理化学性质&存储条件

参考文献

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