BRD3308 |CAS:1550053-02-5 Probechem Biochemicals

Chemical Structure : BRD3308

CAS No.: 1550053-02-5

加入收藏

BRD3308 (BRD 3308)

货号: PC-62401Not For Human Use, Lab Use Only.

BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms.
BRD3308 attenuates PE-mediated phosphorylation of ERK, but not JNK.
BRD3308 also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency.
BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.

物理化学性质&存储条件

分子量	287.294
分子式	C15H14FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Acetylamino-N-(2-amino-4-fluorophenyl)-benzamide

参考文献

1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11.

2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.

3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.

BRD3308 (BRD 3308)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BRD3308 (BRD 3308)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.