BRD 0476 |CAS:1314958-91-2 Probechem Biochemicals

Chemical Structure : BRD0476

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BRD0476 (ML187, BRD 0476, ML 187)

货号: PC-62856Not For Human Use, Lab Use Only.

BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival.

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生物&药学活性

BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival.
BRD 0476 does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities.
The deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.

物理化学性质&存储条件

分子量	674.769
分子式	C35H38N4O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-10-(3-(naphthalen-1-yl)ureido)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide

参考文献

1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34.

2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.

BRD0476 (ML187, BRD 0476, ML 187)

生物&药学活性

物理化学性质&存储条件

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BRD0476 (ML187, BRD 0476, ML 187)

生物&药学活性

物理化学性质&存储条件

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