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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-GSK-3-BRD0320
BRD0320

Chemical Structure : BRD0320

CAS No.: 2446746-26-3

BRD0320 (BRD 0320, BRD-0320)

货号: PC-22892Not For Human Use, Lab Use Only.

BRD0320 is a potent, dual inhibitor of GSK3α/β with Kd of 1.2/1.9 uM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BRD0320 is a potent, dual inhibitor of GSK3α/β with Kd of 1.2/1.9 uM, IC50 of 8/5 nM respectively.

物理化学性质&存储条件

分子量 365.45
分子式 C22H24FN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-cyclopropyl-4-(3-fluorophenyl)-4,7,7-trimethyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one

参考文献

1. Florence F Wagner, et al. Sci Transl Med. 2018 Mar 7;10(431):eaam8460.

2. Mohamed H Yousef, et al. Mol Neurobiol. 2022 Sep;59(9):5591-5611.

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