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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-GSK-3-BRD0209
BRD0209

Chemical Structure : BRD0209

CAS No.: 1597439-87-6

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BRD0209 (BRD 0209)

货号: PC-62876Not For Human Use, Lab Use Only.

BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.

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10 mg ￥2180 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively.
BRD0209 displays remarkable selectivity versus the kinome.
BRD0209 causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h).

物理化学性质&存储条件

分子量 347.462
分子式 C22H25N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-Cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]quinolin-5-one

参考文献

1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.

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