BRD-K98645985

Chemical Structure : BRD-K98645985

CAS No.: 1357647-78-9

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货号: PC-38594Not For Human Use, Lab Use Only.

BRD-K98645985 is a small molecule inhibitor of BAF (mammalian SWI/SNF)-mediated transcription with EC5 of 2.37 uM, binds ARID1A-specific BAF complexes, reverses HIV-1 latency in vitro and ex vivo.

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1 mg	￥4280	In stock
5 mg	￥7280	In stock
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25 mg		Get quote

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生物&药学活性

BRD-K98645985 is a small molecule inhibitor of BAF (mammalian SWI/SNF)-mediated transcription with EC5 of 2.37 uM, binds ARID1A-specific BAF complexes, reverses HIV-1 latency in vitro and ex vivo.
Among the alternate epigenetic targets being investigated for reversing HIV-1 latency, one potential candidate is the mammalian SWI/SNF chromatin remodeling complex, BAF, which has been shown to contribute to HIV-1 transcriptional repression.
BAF complexes are multisubunit ATP-dependent chromatin remodelers known for their roles in development and cancer.

物理化学性质&存储条件

分子量	573.73
分子式	C33H43N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-Methylethyl)-N′-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]urea

参考文献

1. Marian CA, et al. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.

BRD-K98645985

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