BRACO-19 |CAS:1177798-88-7 Probechem Biochemicals

Chemical Structure : BRACO-19

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BRACO-19 (BRACO19)

货号: PC-63060Not For Human Use, Lab Use Only.

BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT).

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生物&药学活性

BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT).
BRACO-19 induces cellular senescence and inhibits growth of uterine cancer cells in vitro.
BRACO-19 inhibits growth of uterine tumor xenografts in vivo.

物理化学性质&存储条件

分子量	703.15
分子式	C35H46Cl3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido) acridine trihydrochloride

参考文献

1. Gowan SM, et al. Mol Pharmacol. 2002 May;61(5):1154-62.

2. Burger AM, et al. Cancer Res. 2005 Feb 15;65(4):1489-96.

3. Incles CM, et al. Mol Pharmacol. 2003 Nov;64(5):1101-8.

4. Gunaratnam M, et al. Biochem Pharmacol. 2009 Jul 15;78(2):115-22.

BRACO-19 (BRACO19)

生物&药学活性

物理化学性质&存储条件

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BRACO-19 (BRACO19)

生物&药学活性

物理化学性质&存储条件

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