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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-BR111
BR111

Chemical Structure : BR111

CAS No.: 1037092-93-5

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BR111 (BR 111)

货号: PC-61772Not For Human Use, Lab Use Only.

BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85  nM (inhibition of hC3a induced Ca2+ release on human macrophages).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85  nM (inhibition of hC3a induced Ca2+ release on human macrophages).
    BR111 displays high selectivity for C3aR over C5aR.
    BR111 inhibits mast cell degranulation, thereby blocking recruitment and activation of macrophages and neutrophils, expression of inflammatory mediators and inflammation in a rat paw edema model.

    物理化学性质&存储条件

    分子量 450.557
    分子式 C24H26N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-benzhydrylthiophene-2-carbonyl)-L-arginine

    参考文献

    1. Lohman RJ, et al. Nat Commun. 2017 Aug 24;8(1):351.

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