BPTU (BMS-646786) | P2Y1 antagonist | Probechem Biochemicals

Chemical Structure : BPTU

CAS No.: 870544-59-5

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BPTU (BMS-646786, BMS646786)

货号: PC-61413Not For Human Use, Lab Use Only.

BPTU (BMS-646786) is a potent, highly selective and allosteric antagonist of P2Y1 receptor with Ki of 6 nM for hP2Y1.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

BPTU (BMS-646786) is a potent, highly selective and allosteric antagonist of P2Y1 receptor with Ki of 6 nM for hP2Y1.
BPTU shows no significant affinity for hP2Y2/6/11/12/14 (Ki>5 uM).
BPTU inhibits purinergic inhibitory junction potentials and inhibition of spontaneous motility induced by electrical field stimulation in the colon of rats (EC50 = 0.3 uM) and mice (EC50 = 0.06 uM).
BPTU also blocks nicotine induced relaxation, has reasonable plasma exposure, clearance and half-life with moderate oral bioavailability.

物理化学性质&存储条件

分子量	445.43
分子式	C23H22F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea

参考文献

1. Chao H, et al. J Med Chem. 2013 Feb 28;56(4):1704-14.

2. Mañé N, et al. Neuropharmacology. 2016 Nov;110(Pt A):376-385.

3. Zhang D, et al. Nature. 2015 Apr 16;520(7547):317-21.

BPTU (BMS-646786, BMS646786)

生物&药学活性

物理化学性质&存储条件

参考文献

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BPTU (BMS-646786, BMS646786)

生物&药学活性

物理化学性质&存储条件

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