BPRCX714 | CXCR4 antagonist | Probechem Biochemicals

Chemical Structure : BPRCX714

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BPRCX714 (BPRCX 714)

货号: PC-49201Not For Human Use, Lab Use Only.

BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.

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生物&药学活性

BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.
BPRCX714 exhibits no cross-activity against a panel of chemokine receptors in both CCR and CXCR types.
BPRCX714 is a promising drug candidate for PBSCT and other disease indications, can mobilize out neutrophils, lymphocytes and monocytes.

物理化学性质&存储条件

分子量	613.812
分子式	C30H51N11O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-(4-((2-(((1-(3-((3-(cyclohexylamino)propyl)amino)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-methylpyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropyl)glycine

参考文献

1. Chien-Huang Wu, et al. J Med Chem. 2018 Feb 8;61(3):818-833.

2. Jen-Shin Song, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2015433118.

BPRCX714 (BPRCX 714)

生物&药学活性

物理化学性质&存储条件

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BPRCX714 (BPRCX 714)

生物&药学活性

物理化学性质&存储条件

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