BPR3P0128

Chemical Structure : BPR3P0128

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货号: PC-22716Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BPR3P0128 is a potent, non-nucleoside viral RNA-dependent RNA polymerase (RdRp) inhibitor with EC05 of 0.66 uM, inhibits influenza viral replication with IC50 of 51-190 nM in MDCK cells, inhibits SARS-CoV-2 variants of concern.
BPR3P0128 demonstrated broad-spectrum activity against various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.
BPR3P0128 does not affect the early entry stage, as evidenced by a time-of-drug-addition assay.
BPR3P0128 effectively reduced the expression of proinflammatory cytokines in human lung epithelial Calu-3 cells infected with SARS-CoV-2.
A combination of BPR3P0128 and remdesivir had a synergistic effect-a result likely due to both drugs interacting with separate domains of the RdRp.

物理化学性质&存储条件

分子量	436.31
分子式	C22H18BrN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Bromo-2-[1-(2,5-dimethylphenyl)-5-methyl-1H-pyrazol-4-yl]-4-quinolinecarboxylic acid

参考文献

1. Tang W-F, et al. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0095623.

2. Hsu JT, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):647-57.

BPR3P0128

生物&药学活性

物理化学性质&存储条件

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BPR3P0128

生物&药学活性

物理化学性质&存储条件

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