BPR1K653 |CAS:1192754-06-5 Probechem Biochemicals

Chemical Structure : BPR1K653

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BPR1K653 (BPR1K 653)

货号: PC-61953Not For Human Use, Lab Use Only.

BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively.

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生物&药学活性

BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively.
BPR1K653 exhibits less potency (IC50>10 uM) in inhibiting the activity of ALK, CHK1, cMET, EGFR, FLT3, VEGFR1 and VEGFR2.
BPR1K653 induces concentration-dependent decrease in phosphor-Aurora-A, -B and -C kinase in HCT116 cells, inhibits the proliferation of multiple human cancer cell lines regardless of their tissue origins and p53 status (IC50s<0.5 uM).
BPR1K653 shows equal potency in inhibiting the growth of the multiple-drug resistance protein (MDR1) -expressing cancer cells.
BPR1K653 also is effective toward MDR1-expressing tumor xenograft.

物理化学性质&存储条件

分子量	541.052
分子式	C30H29ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea

参考文献

1. Cheung CH, et al. PLoS One. 2011;6(8):e23485.

BPR1K653 (BPR1K 653)

生物&药学活性

物理化学性质&存储条件

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BPR1K653 (BPR1K 653)

生物&药学活性

物理化学性质&存储条件

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