BPO-27 racemate |CAS:1314873-02-3 Probechem Biochemicals

Chemical Structure : BPO-27 racemate

CAS No.: 1314873-02-3

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BPO-27 racemate (BPO-27, BPO27)

货号: PC-45712Not For Human Use, Lab Use Only.

BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BPO-27 racemate is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).
BPO-27 racemate shows improved potency, metabolic stability, and aqueous solubility compared to PPQ-102.
BPO-27 racemate prevents cyst growth with IC50 of 100 nM in embryonic kidney culture model of PKD.

物理化学性质&存储条件

分子量	548.34162
分子式	C26H18BrN3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 6 mg/mL
Chemical Name/SMILES	6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-, (6R)-

参考文献

1. Snyder DS, et al. J Med Chem. 2011 Aug 11;54(15):5468-77.

2. Snyder DS, et al. ACS Med Chem Lett. 2013 May 9;4(5):456-459.

3. Kim Y, et al. Mol Pharmacol. 2015 Oct;88(4):689-96.

BPO-27 racemate (BPO-27, BPO27)

生物&药学活性

物理化学性质&存储条件

参考文献

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BPO-27 racemate (BPO-27, BPO27)

生物&药学活性

物理化学性质&存储条件

参考文献

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