BPN-15606 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : BPN-15606

CAS No.: 1914989-49-3

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BPN-15606 (BPN15606)

货号: PC-35198Not For Human Use, Lab Use Only.

BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM.
BPN-15606 does not affect Notch cleavage at 25 uM.
BPN-15606 displays the ability to significantly lower Aβ42 levels in the central nervous system of rats and mice at doses as low as 5-10 mg/kg.
BPN-15606 significantly reduces Aβ neuritic plaque load in an AD transgenic mouse model, and significantly reduces levels of insoluble Aβ42 and pThr181 tau in a three-dimensional human neural cell culture model.

物理化学性质&存储条件

分子量	418.476
分子式	C23H23FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(4-fluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine

参考文献

1. Wagner SL, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44.

BPN-15606 (BPN15606)

生物&药学活性

物理化学性质&存储条件

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BPN-15606 (BPN15606)

生物&药学活性

物理化学性质&存储条件

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