BPN-14136 | RBP4 inhibitor | Probechem Biochemicals

Chemical Structure : BPN-14136

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BPN-14136 (BPN14136)

货号: PC-20718Not For Human Use, Lab Use Only.

BPN-14136 is a potent, selective and non-retinoid RBP4 antagonist with SPA IC50 of 12.8 nM and HTRF IC50 of 43.6 nM.

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生物&药学活性

BPN-14136 is a potent, selective and non-retinoid RBP4 antagonist with SPA IC50 of 12.8 nM and HTRF IC50 of 43.6 nM.
BPN-14136 does not induce human PXR activation, and displays no significant off-target activity at the hERG channel or within a standard screening panel of fifty-five GPCRs, enzymes, ion channels, and transporters.
BPN-14136 induces a robust and sustained lowering (>90%) of serum RBP4 levels upon 7-day QD oral dosing studies conducted in rats.

物理化学性质&存储条件

分子量	391.39
分子式	C20H20F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=NC(N2C[C@]3([H])[C@](C[C@H](C4=CC=CC=C4C(F)(F)F)C3)([H])C2)=NC(C)=C1)O

参考文献

1. Boglarka Racz, et al. J Biol Chem. 2018 Jul 20;293(29):11574-11588.

2. Cioffi C. L et al. J. Med. Chem. 58, 5863–5888 10.1021/acs.jmedchem.5b00423

BPN-14136 (BPN14136)

生物&药学活性

物理化学性质&存储条件

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BPN-14136 (BPN14136)

生物&药学活性

物理化学性质&存储条件

参考文献

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