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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-BPK-29
BPK-29

Chemical Structure : BPK-29

CAS No.: 2143467-62-1

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BPK-29 (BPK29)

货号: PC-60016Not For Human Use, Lab Use Only.

BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
BPK-29 substantially engages NR0B1 (EC50<5 uM) with good overall proteomic selectivity in KEAP1-mutant NSCLCs.
BPK-29 target a conserved cysteine C274 within the NR0B1.

物理化学性质&存储条件

分子量 470.01
分子式 C26H32ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-benzyl-2-chloro-N-(1-(4-morpholinobenzoyl)azepan-4-yl)acetamide

参考文献

1. Bar-Peled L, et al. Cell. 2017 Oct 19;171(3):696-709.e23.

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