BPK-25

Chemical Structure : BPK-25

CAS No.: 2305052-86-0

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货号: PC-23968Not For Human Use, Lab Use Only.

BPK-25 is a small molecule inhibitor of Nucleosome Remodeling and Deacetylation Complex (NuRD), suppresses T-cell activation at low-μM concentrations without causing cytotoxicity.

规格	价格	库存
2 mg	￥1880	In stock
5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

BPK-25 is a small molecule inhibitor of Nucleosome Remodeling and Deacetylation Complex (NuRD), suppresses T-cell activation at low-μM concentrations without causing cytotoxicity.
BPK-25 inhibited TMEM173 activation by the cyclic dinucleotide ligand cGAMP.
BPK-25 blocks NFAT activation, also reduces NFATc2 expression.
BPK-25 promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement.

物理化学性质&存储条件

分子量	392.84
分子式	C21H17ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyridinecarboxamide, 5-[[(6-chloro-2-pyridinyl)methyl](1-oxo-2-propen-1-yl)amino]-N-phenyl-

参考文献

1. Vinogradova EV, et al. Cell. 2020 Aug 20;182(4):1009-1026.e29.

BPK-25

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物理化学性质&存储条件

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BPK-25

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物理化学性质&存储条件

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