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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Guanylate Cyclase-BPIPP
BPIPP

Chemical Structure : BPIPP

CAS No.: 325746-94-9

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BPIPP

货号: PC-62076Not For Human Use, Lab Use Only.

BPIPP is an inhibitor of GC-C (guanylyl cyclase type C) that inhibits stimulation of guanylyl cyclase and adenylyl cyclase, suppresses cGMP accumulation in a variety of cell lines (IC50=3.4-11.2 uM).

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10 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BPIPP is an inhibitor of GC-C (guanylyl cyclase type C) that inhibits stimulation of guanylyl cyclase and adenylyl cyclase, suppresses cGMP accumulation in a variety of cell lines (IC50=3.4-11.2 uM).
BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases.
BPIPP suppresses stable toxin-induced fluid accumulation in an in vivo rabbit intestinal loop model.

物理化学性质&存储条件

分子量 450.28
分子式 C22H16BrN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(3-bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

参考文献

1. Kots AY, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8440-5.

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