BPI-460372

Chemical Structure : BPI-460372

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货号: PC-23994Not For Human Use, Lab Use Only.

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生物&药学活性

BPI-460372 is a potent, orally available, covalent, irreversible inhibitor of TEAD1/3/4, irreversibly binds to the cysteine residue in the TEAD palmitoylation pocket, preventing TEAD palmitoylation and inhibiting its biological function.
BPI-460372 significantly inhibits the expression of a TEAD-responsive element reporter, as well as the mRNA of downstream target genes such as CTGF and CYR61 in NF2-deficient cells.
BPI-460372 strongly inhibited the proliferation of tumor cells harboring Hippo pathway aberrations.
BPI-460372 significantly suppressed tumor growth in NF2-deficient or LATS1/2 mutation xenograft models.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Xiaohong Han, et al. Cancer Res (2024) 84 (6_Supplement): 7575.

2. Hongling Shen, et al. Cancer Res (2023) 83 (7_Supplement): 501.

BPI-460372

生物&药学活性

物理化学性质&存储条件

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BPI-460372

生物&药学活性

物理化学性质&存储条件

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