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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-BPDBA
BPDBA

Chemical Structure : BPDBA

CAS No.: 312281-74-6

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BPDBA

货号: PC-26891Not For Human Use, Lab Use Only.

BPDBA is a potent, subtype selective and noncompetitive inhibitor of betaine/GABA transporter 1 (BGT-1) with IC50 of 20 uM (hBGT-1) and 39 uM ( mouse ortholog mGAT2), shows no activity against hGAT-1/mGAT1, hGAT-2/mGAT3, and hGAT-3/mGAT4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BPDBA is a potent, subtype selective and noncompetitive inhibitor of betaine/GABA transporter 1 (BGT-1) with IC50 of 20 uM (hBGT-1) and 39 uM ( mouse ortholog mGAT2), shows no activity against hGAT-1/mGAT1, hGAT-2/mGAT3, and hGAT-3/mGAT4.

物理化学性质&存储条件

分子量 363.28
分子式 C19H20Cl2N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-Benzyl-4-piperidinyl)-2,4-dichlorobenzamide

参考文献

1. Jørgensen L, et al. J Med Chem. 2017 Nov 9;60(21):8834-8846.

2. Kragholm B, et a. Biochem Pharmacol. 2013 Aug 15;86(4):521-8.

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