Chemical Structure : BPAM344
CAS No.: 1204572-55-3
货号: PC-20090Not For Human Use, Lab Use Only.
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥980 | In stock | |
10 mg | ¥1480 | In stock | |
25 mg | ¥2580 | In stock | |
50 mg | ¥4280 | In stock | |
100 mg | Get quote |
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BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
BPAM344 (100 μM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
BPAM344 stabilizes GluK2 in the closed state in the absence of an agonist or in the presence of DNQX.
分子量 | 242.27 | |
分子式 | C10H11FN2O2S | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide |
1. Etsè KS, et al. ACS Chem Neurosci. 2021 Jul 21;12(14):2679-2692.
2. Larsen AP, et al. Mol Pharmacol. 2017 Jun;91(6):576-585.
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