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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-BPAM344
BPAM344

Chemical Structure : BPAM344

CAS No.: 1204572-55-3

BPAM344 (BPAM-344)

货号: PC-20090Not For Human Use, Lab Use Only.

BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
BPAM344 (100 μM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
BPAM344 stabilizes GluK2 in the closed state in the absence of an agonist or in the presence of DNQX.

物理化学性质&存储条件

分子量 242.27
分子式 C10H11FN2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

参考文献

1. Etsè KS, et al. ACS Chem Neurosci. 2021 Jul 21;12(14):2679-2692.

2. Larsen AP, et al. Mol Pharmacol. 2017 Jun;91(6):576-585.

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