BP-5-087 |CAS:1803281-30-2 Probechem Biochemicals

Chemical Structure : BP-5-087

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BP-5-087 (BP 5-087)

货号: PC-61260Not For Human Use, Lab Use Only.

BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.

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生物&药学活性

BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
BP-5-087 restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.

物理化学性质&存储条件

分子量	770.691
分子式	C36H30F8N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

参考文献

1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597.

2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.

BP-5-087 (BP 5-087)

生物&药学活性

物理化学性质&存储条件

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BP-5-087 (BP 5-087)

生物&药学活性

物理化学性质&存储条件

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