欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-RET Tyrosine Kinase (c-RET)-BOS172738
BOS172738

Chemical Structure : BOS172738

CAS No.: 2216753-97-6

加入收藏

BOS172738 (Zeteletinib, DS 5010)

货号: PC-72475Not For Human Use, Lab Use Only.

BOS172738 (Zeteletinib, DS 5010) is a potent, selective oral RET kinase inhibitor with nanomolar potency against wtRET and RET mutations (Ki <1 nM), >300-fold selectivity against VEGFR2.

规格 价格 库存 数量
2 mg ￥2180 In stock
5 mg ￥3580 In stock
10 mg ￥5580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BOS172738 (Zeteletinib, DS 5010) is a potent, selective oral RET kinase inhibitor with nanomolar potency against wtRET and RET mutations (Ki <1 nM), >300-fold selectivity against VEGFR2.
BOS172738 demonstrated exquisite potency for RET and RET mutations with Kd values <1 nM for RETwt, RET(M918T), RET(V804L) and RET(V804M), also demonstrated high selectivity over KDR.
BOS172738 demonstrated similar potency to ponatinib (IC50=0.5 uM) in inhibiting the in vitro proliferation of a NCO4-RET human CRC cell line (CR1520).
BOS172738 significantly less anti-proliferative activity in HUVEC normal endothelial cells (IC50=2.9 uM).
BOS172738 demonstrated potent and durable tumor regression at doses of 30 mg/kg in NSCLC PDX model (CTG-0838:KIF5B-RET), also demonstrated potent tumor regression on larger, established tumors.

物理化学性质&存储条件

分子量 500.48
分子式 C25H23F3N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[6-(6,7-dimethoxyquinolin-3-yl)pyridin-3-yl]-N-[3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-5-yl]acetamide

参考文献

1. Mitchell Keegan, et al. Cancer Res (2019) 79 (13_Supplement): 2199.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: