BOS172722 |CAS:1578245-44-9 Probechem Biochemicals

Chemical Structure : BOS172722

CAS No.: 1578245-44-9

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BOS172722 (BOS-172722;BOS 172722)

货号: PC-35662Not For Human Use, Lab Use Only.

BOS172722 (BOS-172722) is a potent, selective MPS1 kinase (TTK) inhibitor with biochemical IC50 of 11 nM, 100-fold selectivity over CDK2.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
50 mg	￥6580	In stock
100 mg	￥9580	In stock
500 mg		Get quote
1 g		Get quote

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生物&药学活性

BOS172722 (BOS-172722) is a potent, selective MPS1 kinase (TTK) inhibitor with biochemical IC50 of 11 nM.
BOS172722 displays 100-fold selectivity over CDK2.
BOS172722 potently inhibits autophosphorylation of ectopically expressed MPS1 in HCT116 cells with IC50 of 63 nM.
BOS172722 demonstrates excellent selectivity against a wide panel of more than 400 kinases as well as a clean CYP and hERG profile.
BOS172722 exhibits robust efficacy in combination with paclitaxel in in vivo models.

物理化学性质&存储条件

分子量	446.559
分子式	C24H30N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine

参考文献

1. Woodward HL, et al. J Med Chem. 2018 Sep 27;61(18):8226-8240.

BOS172722 (BOS-172722;BOS 172722)

生物&药学活性

物理化学性质&存储条件

参考文献

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BOS172722 (BOS-172722;BOS 172722)

生物&药学活性

物理化学性质&存储条件

参考文献

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