BOS-318 | Furin inhibitor | Probechem Biochemicals

Chemical Structure : BOS-318

CAS No.: 2387633-15-8

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BOS-318 (BOS318)

货号: PC-72839Not For Human Use, Lab Use Only.

BOS-318 (BOS318) is a potent, highly selective, cell-permeable furin inhibitor with IC50 of 1.9 nM, Ki of 0.4 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

BOS-318 (BOS318) is a potent, highly selective, cell-permeable furin inhibitor with IC50 of 1.9 nM, Ki of 0.4 nM.
BOS-318 displays 13 times more potent against furin than PCSK5 (IC50 =25.3 nM), 24 times more potent than PCSK7 (IC50 =45.8 nM), and 110 times more potent than PCSK6 (IC50 =209.4 nM).
BOS-318 reduces endogenous proteases in the Golgi compartment in U2OS cells with IC50 of 23.5 nM.
BOS-318 provides protection against PEA-mediated cytotoxicity in a dose-dependent manner in CuFi-1 cells, over a period of 72 h, with an EC50 of 47.8 nM.
BOS-318 reduces ENaC-mediated Na+ absorption in CF HBECs after short- (2-h) and long-term (48-h) treatment and protects against NE- and CF sputum-sol-mediated activation of the ENaC.

物理化学性质&存储条件

分子量	571.503
分子式	C28H32Cl2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-((2-(3,5-dichlorophenyl)-6-((2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)oxy)pyridin-4-yl)methyl)piperidin-4-yl)acetic acid

参考文献

1. Lisa E J Douglas, et al. Cell Chem Biol. 2022 Feb 22;S2451-9456(22)00052-6.

BOS-318 (BOS318)

生物&药学活性

物理化学性质&存储条件

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BOS-318 (BOS318)

生物&药学活性

物理化学性质&存储条件

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