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首页-小分子抑制剂&激动剂-Others-Other Targets-BO-264
BO-264

Chemical Structure : BO-264

CAS No.: 2408648-20-2

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BO-264 (BO264)

货号: PC-38168Not For Human Use, Lab Use Only.

BO-264 (BO264) is a highly potent inhibitor of transforming acidic coiled-coil (TACC) family member TACC3 (IC50=188 nM).

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BO-264 (BO264) is a highly potent inhibitor of transforming acidic coiled-coil (TACC) family member TACC3 (IC50=188 nM).
The interaction between TACC3 and BO-264 with a dissociation constant, KD of 1.5 nM.
BO-264 inhibits the viability of cancer cells with FGFR3–TACC3 fusion and shows very potent cytotoxicity in NCI-60 cancer cell line panel.
TACC3 inhibition with BO-264 induces mitotic arrest, apoptosis, and DNA damage, causes aberrant spindle formation, and reduces centrosomal localization of TACC3.
BO-264 significantly impairs tumor growth and improves survival in in vivo xenograft and syngeneic models without major toxicity.

物理化学性质&存储条件

分子量 353.382
分子式 C18H19N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine

参考文献

1. Ozge Akbulut, et al. Mol Cancer Ther. 2020 Jun;19(6):1243-1254.

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