BNZ-111 | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : BNZ-111

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BNZ-111 (BNZ111)

货号: PC-23110Not For Human Use, Lab Use Only.

BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.

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生物&药学活性

BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.
BNZ-111 prevents tubulin from adapting a straight structure
BNZ-111 shows a significant tumor growth inhibition in vivo in Paclitaxel resistant HeyA8-MDR human ovarian cancer bearing mice models without significant body weight change.
BNZ-111 possesses good drug-like properties for as oral drug.

物理化学性质&存储条件

分子量	265.29
分子式	C13H16FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-fluoro-6-propoxy-1H-benzo[d]imidazol-2-yl)propionamide

参考文献

1. Jiyoon Jang, et al. Bioorg Med Chem Lett. 2024 Sep 11:113:129953.

BNZ-111 (BNZ111)

生物&药学活性

物理化学性质&存储条件

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BNZ-111 (BNZ111)

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