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首页-小分子抑制剂&激动剂-Others-Other Targets-BNZ-1
BNZ-1

Chemical Structure : BNZ-1

CAS No.:

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BNZ-1 (BNZ132-1-40)

货号: PC-38315Not For Human Use, Lab Use Only.

BNZ-1 (BNZ132-1-40) is a pegylated peptide, BNZ132-1 conjugated with methoxy-PEG40 maleimide molecule via a specific linker (CGSGG), specifically binds the γc receptor to selectively block IL-2, IL-15 and IL-9 signaling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BNZ-1 (BNZ132-1-40) is a pegylated peptide, BNZ132-1 conjugated with methoxy-PEG40 maleimide molecule via a specific linker (CGSGG), specifically binds the γc receptor to selectively block IL-2, IL-15 and IL-9 signaling.
    BNZ-1 (BNZ132-1-40) is a helical peptide designed to bind directly to the γc molecule and is PEGylated to increase its half-life, selectively block IL-2, IL-15, and IL-9 binding while leaving other γc and non-γc cytokine signaling unaffected.
    BNZ-1 effectively inhibited ex vivo HTLV-1 associated myelopathy/ tropical spastic paraparesis PBMC proliferation and in vivo proliferation of murine CD8+ T cell leukemia in an IL-15 transgenic mouse model.
    BNZ-1 exhibited no adverse effects on other immune cells and maintained selectivity for Tregs, CD8+ T and NK cells.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    Chemical Name/SMILES

    PEG40-CGSGG-QITISILSQINRVFHEKFI

    参考文献

    1. Toshie Nata, et al. J Biol Chem. 2015 Sep 11;290(37):22338-51.

    2. T Tiffany Wang, et al. Leukemia. 2019 May;33(5):1243-1255.

    3. Raya Massoud, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11030-5.

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