BNM-III-170 trifluoroacetate |CAS:1859189-55-1 Probechem Biochemicals

Chemical Structure : BNM-III-170 trifluoroacetate

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BNM-III-170 trifluoroacetate (BNM-III-170 TFA)

货号: PC-35227Not For Human Use, Lab Use Only.

BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.
BNM-III-170 TFA binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies.
BNM-III-170 TFA synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).

物理化学性质&存储条件

分子量	674.958
分子式	C25H26ClF7N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-chloro-3-fluorophenyl)-N2-((1R,2R)-2-(guanidinomethyl)-5-((methylamino)methyl)-2,3-dihydro-1H-inden-1-yl)oxalamide bis(2,2,2-trifluoroacetate)

参考文献

1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363.

BNM-III-170 trifluoroacetate (BNM-III-170 TFA)

生物&药学活性

物理化学性质&存储条件

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BNM-III-170 trifluoroacetate (BNM-III-170 TFA)

生物&药学活性

物理化学性质&存储条件

参考文献

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