BNM-III-170 |CAS:1859189-54-0 Probechem Biochemicals

Chemical Structure : BNM-III-170

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BNM-III-170

货号: PC-35228Not For Human Use, Lab Use Only.

BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.

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生物&药学活性

BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo.
BNM-III-170 binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies.
BNM-III-170 synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).

物理化学性质&存储条件

分子量	446.911
分子式	C21H24ClFN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-chloro-3-fluorophenyl)-N2-((1R,2R)-2-(guanidinomethyl)-5-((methylamino)methyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

参考文献

1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363.

BNM-III-170

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BNM-III-170

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