Soclenicant (BNC210, BNC-210) | α7 nAChR PAM | Probechem Biochemicals

Chemical Structure : BNC210

加入收藏

BNC210 (Soclenicant, BNC-210)

货号: PC-21672Not For Human Use, Lab Use Only.

Soclenicant (BNC210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Soclenicant (BNC210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
BNC210 inhibits acetylcholine, nicotine, choline and PNU-282987.
BNC210 is not active at other members of the cys-loop ligand gated ion channel family when tested at 3 and 10 μM for selectivity against the α1β1δε, α3β4, α4β2 nAChRs and the 5HT3a and GABAA receptors in a Ca++ flux fluorescence-based functional assay.
BNC210 demonstrates anxiolytic-like behavior in rodent tests.

物理化学性质&存储条件

分子量	418.50
分子式	C24H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one

参考文献

1. O'Connor SM, et al. Neuropharmacology. 2024 Jan 5:109836.

BNC210 (Soclenicant, BNC-210)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BNC210 (Soclenicant, BNC-210)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.