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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-BNBI
BNBI

Chemical Structure : BNBI

CAS No.: 51877-67-9

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BNBI

货号: PC-60575Not For Human Use, Lab Use Only.

BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM.
    BNBI has no detectable effect on uterine contractility in the GD15 mouse at 100 uM.

    物理化学性质&存储条件

    分子量 366.337
    分子式 C17H14N6O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,3-Bis(5-nitro-1H-benzo[d]imidazol-2-yl)propane

    参考文献

    1. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.

    2. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103.

    3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74.

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