BN201 | SGK2 activator | Probechem Biochemicals

Chemical Structure : BN201

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BN201 (OCS-05)

货号: PC-24808Not For Human Use, Lab Use Only.

BN201 (OCS-05, aka BN201) is a peptidomimetic that binds to serum glucocorticoid kinase-2 (SGK2) with neuroprotective activity, activates SGK2, thereby activating FOXO3 pathway.

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生物&药学活性

BN201 (OCS-05, aka BN201) is a peptidomimetic that binds to serum glucocorticoid kinase-2 (SGK2) with neuroprotective activity, activates SGK2, thereby activating FOXO3 pathway.
BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors.
BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes in vitro, and the myelination of new axons, promotes the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro, and the myelination of new axons (EC50 of 16.6 μM).
BN201 modulates several kinases participating in the insulin growth factor 1 pathway including serum-glucocorticoid kinase and midkine, inducing the phosphorylation of NDRG1 and the translocation of the transcription factor Foxo3 to the cytoplasm.
BN201 prevents axonal and neuronal loss, and it promotes remyelination in models of multiple sclerosis, chemically induced demyelination, and glaucoma.
BN201 has demonstrated neuroprotective properties by reducing the damage in the optic nerve and retina in in vivo models of acute optic neuritis (AON) such as lysolecithin-induced optic nerve demyelination, and in the experimental autoimmune encephalomyelitis model of MS.

物理化学性质&存储条件

分子量	491.61
分子式	C25H38FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Glycinamide, N-[2-(2-fluorophenyl)ethyl]glycyl-N-(2-methylpropyl)glycyl-N2-[3-(2-oxo-1-pyrrolidinyl)propyl]-

参考文献

1. Pablo Villoslada, et al. Neurotherapeutics. 2019 Jul;16(3):808-827.

BN201 (OCS-05)

生物&药学活性

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BN201 (OCS-05)

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