BMY 45778 |CAS:152575-66-1 Probechem Biochemicals

Chemical Structure : BMY 45778

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BMY 45778 (BMY-45778, BMY45778)

货号: PC-60722Not For Human Use, Lab Use Only.

BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.

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生物&药学活性

BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
BMY 45778 activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations.
BMY 45778 prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets.

物理化学性质&存储条件

分子量	438.44
分子式	C26H18N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid

参考文献

1. Meanwell NA, et al. J Med Chem. 1993 Nov 26;36(24):3884-903.

2. Seiler SM, et al. Prostaglandins. 1997 Jan;53(1):21-35.

3. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.

4. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.

BMY 45778 (BMY-45778, BMY45778)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMY 45778 (BMY-45778, BMY45778)

生物&药学活性

物理化学性质&存储条件

参考文献

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