BMX-IN-1 |CAS:1431525-23-3 Probechem Biochemicals

Chemical Structure : BMX-IN-1

CAS No.: 1431525-23-3

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BMX-IN-1 (BMX kinase inhibitor)

货号: PC-46005Not For Human Use, Lab Use Only.

BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM.
BMX-IN-1 also inhibits BTK with IC50 of 10.4 nM and displays 47-656-fold less potent for Blk, JAK3, EGFR, Itk, or Tec.
BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with GI50 of 25 nM, exhibits antiproliferative activity in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines with GI50 of 2-5 uM.

物理化学性质&存储条件

分子量	524.5903
分子式	C29H24N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-

参考文献

1. Liu F, et al. ACS Chem Biol. 2013 Jul 19;8(7):1423-8.

BMX-IN-1 (BMX kinase inhibitor)

生物&药学活性

物理化学性质&存储条件

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BMX-IN-1 (BMX kinase inhibitor)

生物&药学活性

物理化学性质&存储条件

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