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首页-小分子抑制剂&激动剂-GPCR-mGluR-BMT-145027
BMT-145027

Chemical Structure : BMT-145027

CAS No.: 2018282-44-3

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BMT-145027 (BMT 145027, BMT145027)

货号: PC-61069Not For Human Use, Lab Use Only.

BMT-145027 is a potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM).

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5 mg ￥1580 In stock
10 mg ￥2380 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMT-145027 is a potent, selective, non-MPEP site mGluR5 positive allosteric modulator with EC50 of 47 nM, without inherent mGluR5 agonist activity (EC50>16 uM).
BMT-145027 does not engage the receptor at the MPEP and CPPHA allosteric sites.
BMT-145027 improves cognition in a preclinical rodent model of learning and memory.

物理化学性质&存储条件

分子量 438.838
分子式 C23H14ClF3N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-chloro-3-(trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

参考文献

1. Hill MD, et al. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.

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