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BMS433771

Chemical Structure : BMS433771

CAS No.: 543700-68-1

BMS433771 (BMS-433771)

货号: PC-63269Not For Human Use, Lab Use Only.

BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM; inhibits the fusion of lipid membranes during both the early virus entry stage and late-stage syncytium formation; A series of single amino acid mutations in the F1 subunit of the fusion protein confers resistance to BMS433771.

物理化学性质&存储条件

分子量 377.448
分子式 C21H23N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one

参考文献

1. Cianci C, et al. Antimicrob Agents Chemother. 2004 Feb;48(2):413-22.

2. Cianci C, et al. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.

3. Cianci C, et al. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15046-51.

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