BMS191095 | KATP opener | Probechem Biochemicals

Chemical Structure : BMS191095

CAS No.: 166095-21-2

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BMS191095 (BMS-191095)

货号: PC-22096Not For Human Use, Lab Use Only.

BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM.

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10 mg	￥4780	In stock
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生物&药学活性

BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM.
BMS191095 is over 20- and 4000-fold more selective for the ischemic myocardium than BMS-180448 and cromakalim.
BMS191095 is devoid of peripheral vasodilating activity while retaining glyburide-reversible cardioprotective activity.
BMS-191095 improved postischemic recovery of function and reduced lactate dehydrogenase release in the isolated rat hearts.
BMS-191095 opened cardiac mitochondrial K(ATP) with a K(1/2) of 83 nM.

物理化学性质&存储条件

分子量	408.89
分子式	C22H21ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

参考文献

1. Rovnyak GC, et al. J Med Chem. 1997 Jan 3;40(1):24-34.

2. Grover GJ, et al. J Pharmacol Exp Ther. 2001 Jun;297(3):1184-92.

BMS191095 (BMS-191095)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS191095 (BMS-191095)

生物&药学活性

物理化学性质&存储条件

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