BMS-986308 | ROMK inhibitor | Probechem Biochemicals

Chemical Structure : BMS-986308

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BMS-986308 (BMS986308)

货号: PC-22457Not For Human Use, Lab Use Only.

BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM.

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生物&药学活性

BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM.
BMS-986308 displays no inhibitory potency against related inwardly rectifying potassium channels (Kir2.1, Kir2.3, Kir4.1, and Kir7.1), as well as an internal panel of 49 GPCRs, enzymes, and ion channels.
BMS-986308 demonstrated efficacy in the volume-loaded rat diuresis model as well as promising in vitro and in vivo profiles.

物理化学性质&存储条件

分子量	443.51
分子式	C24H25N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[4-[[(3R,5S)-3-(1,3-Dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-5-methyl-1-piperazinyl]methyl]-2H-1,2,3-triazol-2-yl]-4-methyl-3-pyridinecarbonitrile

参考文献

1. Jeremy M Richter, et al. J Med Chem. 2024 Jun 13;67(11):9731-9744.

BMS-986308 (BMS986308)

生物&药学活性

物理化学性质&存储条件

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询单

BMS-986308 (BMS986308)

生物&药学活性

物理化学性质&存储条件

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