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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-BMS-986256
BMS-986256

Chemical Structure : BMS-986256

CAS No.: 2171019-55-7

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BMS-986256 (Afimetoran, BMS986256)

货号: PC-72474Not For Human Use, Lab Use Only.

BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-986256 (Afimetoran, BMS986256) is an orally active, potent and selective inhibitor antagonist of TLR7/8.
BMS-986256 has demonstrated efficacy in animal models of lupus as well as favorable PK and acceptable safety profiles in healthy subjects.

物理化学性质&存储条件

分子量 444.6
分子式 C26H32N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]acetamide

参考文献

1. U Ranganathan et al. PO.6.132 A phase 2b study of afimetoran (BMS-986256) in patients with active systemic lupus erythematosus (SLE): optimization of a lupus clinical trial design.

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